Here is another one of those words that you see more than you hear (like emoticon). I think I first heard of them from Scott Hanselman while reading about his personal systems of organization (very good). Anywho, last week on my flight home from KC I was listening to Scott's podcast, Hanselminutes show #18, and he discussed his personal organization system. In that I heard him pronounce Moleskine and boy what I waaaay off on the pronunciation.
I wouldn't have guessed it in 25 tries. I've always pronounced it as mole-skin or mole-skine. Negative, it's mol-a-skeen-a.
ps. I use the regular size ruled notebook.